Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Cohesin complex disruption alters gene expression, and cohesin mutations are common in myeloid neoplasia, suggesting a critical role in hematopoiesis. Here, we explore cohesin dynamics and regulation of hematopoietic stem cell homeostasis and differentiation. Cohesin binding increases at active regu...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Sasca, Daniel, Yun, Haiyang, Giotopoulos, George, Szybinski, Jakub, Evan, Theo, Wilson, Nicola K., Gerstung, Moritz, Gallipoli, Paolo, Green, Anthony R., Hills, Robert, Russell, Nigel, Osborne, Cameron S., Papaemmanuil, Elli, Göttgens, Berthold, Campbell, Peter, Huntly, Brian J. P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2019
Aiheet:
Myeloid Neoplasia
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484777/
https://ncbi.nlm.nih.gov/pubmed/31515253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001553
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