The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia

Growing evidence links abnormal epigenetic control to the development of hematological malignancies. Accordingly, inhibition of epigenetic regulators is emerging as a promising therapeutic strategy. The acetylation status of lysine residues in histone tails is one of a number of epigenetic post-tran...

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Gepubliceerd in:Oncogene
Hoofdauteurs: Giotopoulos, G, Chan, W-I, Horton, SJ, Ruau, D, Gallipoli, P, Fowler, A, Crawley, C, Papaemmanuil, E, Campbell, PJ, Göttgens, B, Van Deursen, JM, Cole, PA, Huntly, BJP
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729186/
https://ncbi.nlm.nih.gov/pubmed/25893291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.92
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