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Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112

The histone acetyltransferase (HAT) enzymes p300 and CBP are closely related paralogs that serve as transcriptional coactivators and have been found to be dysregulated in cancer and other diseases. p300/CBP is a multidomain protein and possesses a highly conserved bromodomain that has been shown to...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Zucconi, Beth E., Luef, Birgit, Xu, Wei, Henry, Ryan A., Nodelman, Ilana M., Bowman, Gregory D., Andrews, Andrew J., Cole, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007619/
https://ncbi.nlm.nih.gov/pubmed/27332697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00480
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