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Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP
p300 and CBP are highly related histone acetyltransferase (HAT) enzymes that regulate gene expression, and their dysregulation has been linked to cancer and other diseases. p300/CBP is composed of a number of domains including a HAT domain which is inhibited by the small molecule A-485 and an acetyl...
Gorde:
| Argitaratua izan da: | Biochemistry |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6948846/ https://ncbi.nlm.nih.gov/pubmed/30924641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00160 |
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