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Analysis of p300/CBP Histone Acetyltransferase Regulation Using Circular Permutation and Semisynthesis
[Image: see text] The histone acetyltransferase (HAT) p300/CBP has been shown to undergo autoacetylation on lysines in an apparent regulatory loop that stimulates HAT activity. Here we developed a strategy to introduce acetyl-Lys at up to six known modification sites in p300/CBP HAT using a combinat...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2811879/ https://ncbi.nlm.nih.gov/pubmed/20063892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja909466d |
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