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Analysis of p300/CBP Histone Acetyltransferase Regulation Using Circular Permutation and Semisynthesis

[Image: see text] The histone acetyltransferase (HAT) p300/CBP has been shown to undergo autoacetylation on lysines in an apparent regulatory loop that stimulates HAT activity. Here we developed a strategy to introduce acetyl-Lys at up to six known modification sites in p300/CBP HAT using a combinat...

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Detalhes bibliográficos
Main Authors: Karukurichi, Kannan R., Wang, Ling, Uzasci, Lerna, Manlandro, Cara Marie, Wang, Qing, Cole, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811879/
https://ncbi.nlm.nih.gov/pubmed/20063892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja909466d
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