Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases

[Image: see text] p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel, highly selective, orally bioavailable histone acetyltransferase (HAT) domain inhibitor has been id...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Michaelides, Michael R., Kluge, Arthur, Patane, Michael, Van Drie, John H., Wang, Ce, Hansen, T. Matthew, Risi, Roberto M., Mantei, Robert, Hertel, Carmen, Karukurichi, Kannan, Nesterov, Alexandre, McElligott, David, de Vries, Peter, Langston, J. William, Cole, Philip A., Marmorstein, Ronen, Liu, Hong, Lasko, Loren, Bromberg, Kenneth D., Lai, Albert, Kesicki, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767893/
https://ncbi.nlm.nih.gov/pubmed/29348807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00395
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