Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases

[Image: see text] p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel, highly selective, orally bioavailable histone acetyltransferase (HAT) domain inhibitor has been id...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Med Chem Lett
मुख्य लेखकों: Michaelides, Michael R., Kluge, Arthur, Patane, Michael, Van Drie, John H., Wang, Ce, Hansen, T. Matthew, Risi, Roberto M., Mantei, Robert, Hertel, Carmen, Karukurichi, Kannan, Nesterov, Alexandre, McElligott, David, de Vries, Peter, Langston, J. William, Cole, Philip A., Marmorstein, Ronen, Liu, Hong, Lasko, Loren, Bromberg, Kenneth D., Lai, Albert, Kesicki, Edward A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2017
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767893/
https://ncbi.nlm.nih.gov/pubmed/29348807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00395
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