Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases

[Image: see text] p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel, highly selective, orally bioavailable histone acetyltransferase (HAT) domain inhibitor has been id...

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Publicat a:ACS Med Chem Lett
Autors principals: Michaelides, Michael R., Kluge, Arthur, Patane, Michael, Van Drie, John H., Wang, Ce, Hansen, T. Matthew, Risi, Roberto M., Mantei, Robert, Hertel, Carmen, Karukurichi, Kannan, Nesterov, Alexandre, McElligott, David, de Vries, Peter, Langston, J. William, Cole, Philip A., Marmorstein, Ronen, Liu, Hong, Lasko, Loren, Bromberg, Kenneth D., Lai, Albert, Kesicki, Edward A.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2017
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767893/
https://ncbi.nlm.nih.gov/pubmed/29348807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00395
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