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Probing the Reaction Coordinate of the p300/CBP Histone Acetyltranferase with Bisubstrate Analogs

Histone and protein acetylation catalyzed by p300/CBP transcriptional coactivator regulates a variety of key biological pathways. This study investigates the proposed Theorell-Chance or “hit-and-run” catalytic mechanism of p300/CBP histone acetyltransferase (HAT) using bisubstrate analogs. A range o...

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Autores principales: Karukurichi, Kannan R., Cole, Philip A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076313/
https://ncbi.nlm.nih.gov/pubmed/21111442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2010.10.004
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