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Probing the Reaction Coordinate of the p300/CBP Histone Acetyltranferase with Bisubstrate Analogs
Histone and protein acetylation catalyzed by p300/CBP transcriptional coactivator regulates a variety of key biological pathways. This study investigates the proposed Theorell-Chance or “hit-and-run” catalytic mechanism of p300/CBP histone acetyltransferase (HAT) using bisubstrate analogs. A range o...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076313/ https://ncbi.nlm.nih.gov/pubmed/21111442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2010.10.004 |
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