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Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP

p300 and CBP are highly related histone acetyltransferase (HAT) enzymes that regulate gene expression, and their dysregulation has been linked to cancer and other diseases. p300/CBP is composed of a number of domains including a HAT domain which is inhibited by the small molecule A-485 and an acetyl...

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書目詳細資料
發表在:Biochemistry
Main Authors: Zucconi, Beth E., Makofske, Jessica L., Meyers, David J., Hwang, Yousang, Wu, Mingxuan, Kuroda, Mitzi I., Cole, Philip A.
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948846/
https://ncbi.nlm.nih.gov/pubmed/30924641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00160
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