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Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP
p300 and CBP are highly related histone acetyltransferase (HAT) enzymes that regulate gene expression, and their dysregulation has been linked to cancer and other diseases. p300/CBP is composed of a number of domains including a HAT domain which is inhibited by the small molecule A-485 and an acetyl...
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| 出版年: | Biochemistry |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6948846/ https://ncbi.nlm.nih.gov/pubmed/30924641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00160 |
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