A rare subgroup of leukemia stem cells harbours relapse-inducing potential in acute lymphoblastic leukemia

Por Senft, Daniela, Jeremias, Irmela
Publicado no Exp Hematol (2019)

Efficient RNA interference in patients' acute lymphoblastic leukemia cells amplified as xenografts in mice

Por Höfig, Ines, Ehrhardt, Harald, Jeremias, Irmela
Publicado em 2012

Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling

Por Wachter, Franziska, Grunert, Michaela, Blaj, Cristina, Weinstock, David M, Jeremias, Irmela, Ehrhardt, Harald
Publicado em 2013

CLUE: a bioinformatic and wet-lab pipeline for multiplexed cloning of custom sgRNA libraries

Por Becker, Martin, Noll-Puchta, Heidi, Amend, Diana, Nolte, Florian, Fuchs, Christiane, Jeremias, Irmela, Braun, Christian J
Publicado no Nucleic Acids Res (2020)

Anti-leukemic effects of the V-ATPase inhibitor Archazolid A

Por Zhang, Siwei, Schneider, Lina S., Vick, Binje, Grunert, Michaela, Jeremias, Irmela, Menche, Dirk, Müller, Rolf, Vollmar, Angelika M., Liebl, Johanna
Publicado no Oncotarget (2015)

The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis

Por Kirsch, Volker C., Orgler, Christina, Braig, Simone, Jeremias, Irmela, Auerbach, David, Müller, Rolf, Vollmar, Angelika M., Sieber, Stephan A.
Publicado no Angew Chem Int Ed Engl (2019)

CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons

Por Martin-Villalba, Ana, Herr, Ingrid, Jeremias, Irmela, Hahne, Michael, Brandt, Roland, Vogel, Johannes, Schenkel, Johannes, Herdegen, Thomas, Debatin, Klaus-Michael
Publicado no J Neurosci (1999)

Targeting the endoplasmic reticulum-mitochondria interface sensitizes leukemia cells to cytostatics

Por Koczian, Fabian, Nagło, Olga, Vomacka, Jan, Vick, Binje, Servatius, Phil, Zisis, Themistoklis, Hettich, Britta, Kazmaier, Uli, Sieber, Stephan A., Jeremias, Irmela, Zahler, Stefan, Braig, Simone
Publicado no Haematologica (2019)

Smac Mimetic Bypasses Apoptosis Resistance in FADD- or Caspase-8-Deficient Cells by Priming for Tumor Necrosis Factor α-Induced Necroptosis

Por Laukens, Bram, Jennewein, Claudia, Schenk, Barbara, Vanlangenakker, Nele, Schier, Alexander, Cristofanon, Silvia, Zobel, Kerry, Deshayes, Kurt, Vucic, Domagoj, Jeremias, Irmela, Bertrand, Mathieu JM, Vandenabeele, Peter, Fulda, Simone
Publicado em 2011

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Por Liu, Wen-Hsin, Mrozek-Gorska, Paulina, Wirth, Anna-Katharina, Herold, Tobias, Schwarzkopf, Larissa, Pich, Dagmar, Völse, Kerstin, Melo-Narváez, M. Camila, Carlet, Michela, Hammerschmidt, Wolfgang, Jeremias, Irmela
Publicado no Biomark Res (2020)

In Vivo Imaging Enables High Resolution Preclinical Trials on Patients’ Leukemia Cells Growing in Mice

Por Terziyska, Nadia, Alves, Catarina Castro, Groiss, Volker, Schneider, Katja, Farkasova, Katarina, Ogris, Manfred, Wagner, Ernst, Ehrhardt, Harald, Brentjens, Renier J., zur Stadt, Udo, Horstmann, Martin, Quintanilla-Martinez, Leticia, Jeremias, Irmela
Publicado em 2012

An Advanced Preclinical Mouse Model for Acute Myeloid Leukemia Using Patients' Cells of Various Genetic Subgroups and In Vivo Bioluminescence Imaging

Por Vick, Binje, Rothenberg, Maja, Sandhöfer, Nadine, Carlet, Michela, Finkenzeller, Cornelia, Krupka, Christina, Grunert, Michaela, Trumpp, Andreas, Corbacioglu, Selim, Ebinger, Martin, André, Maya C., Hiddemann, Wolfgang, Schneider, Stephanie, Subklewe, Marion, Metzeler, Klaus H., Spiekermann, Karsten, Jeremias, Irmela
Publicado no PLoS One (2015)

Spatiotemporal patterning of EpCAM is important for murine embryonic endo- and mesodermal differentiation

Por Sarrach, Sannia, Huang, Yuanchi, Niedermeyer, Sebastian, Hachmeister, Matthias, Fischer, Laura, Gille, Sebastian, Pan, Min, Mack, Brigitte, Kranz, Gisela, Libl, Darko, Merl-Pham, Juliane, Hauck, Stefanie M., Paoluzzi Tomada, Elisa, Kieslinger, Matthias, Jeremias, Irmela, Scialdone, Antonio, Gires, Olivier
Publicado no Sci Rep (2018)

ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells

Por Redondo Monte, Enric, Wilding, Anja, Leubolt, Georg, Kerbs, Paul, Bagnoli, Johannes W., Hartmann, Luise, Hiddemann, Wolfgang, Chen-Wichmann, Linping, Krebs, Stefan, Blum, Helmut, Cusan, Monica, Vick, Binje, Jeremias, Irmela, Enard, Wolfgang, Theurich, Sebastian, Wichmann, Christian, Greif, Philipp A.
Publicado no Oncogene (2020)

RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade

Por Ruzicka, Michael, Koenig, Lars M., Formisano, Simone, Boehmer, Daniel F. R., Vick, Binje, Heuer, Eva-M., Meinl, Hanna, Kocheise, Lorenz, Zeitlhöfler, Marcus, Ahlfeld, Julia, Kobold, Sebastian, Endres, Stefan, Subklewe, Marion, Duewell, Peter, Schnurr, Max, Jeremias, Irmela, Lichtenegger, Felix S., Rothenfusser, Simon
Publicado no Leukemia (2019)

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML wi...

Por Garz, Anne-Kathrin, Wolf, Saskia, Grath, Sonja, Gaidzik, Verena, Habringer, Stefan, Vick, Binje, Rudelius, Martina, Ziegenhain, Christoph, Herold, Sylvia, Weickert, Marie-Theresa, Smets, Martha, Peschel, Christian, Oostendorp, Robert A.J., Bultmann, Sebastian, Jeremias, Irmela, Thiede, Christian, Döhner, Konstanze, Keller, Ulrich, Götze, Katharina S.
Publicado no Oncotarget (2017)

Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics

Por Habringer, Stefan, Lapa, Constantin, Herhaus, Peter, Schottelius, Margret, Istvanffy, Rouzanna, Steiger, Katja, Slotta-Huspenina, Julia, Schirbel, Andreas, Hänscheid, Heribert, Kircher, Stefan, Buck, Andreas K., Götze, Katharina, Vick, Binje, Jeremias, Irmela, Schwaiger, Markus, Peschel, Christian, Oostendorp, Robert, Wester, Hans-Jürgen, Grigoleit, Götz-Ulrich, Keller, Ulrich
Publicado no Theranostics (2018)

Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL

Por Siekmann, Ina-Katrin, Dierck, Kevin, Prall, Sebastian, Klokow, Marianne, Strauss, Julia, Buhs, Sophia, Wrzeszcz, Antonina, Bockmayr, Michael, Beck, Florian, Trochimiuk, Magdalena, Gottschling, Kristina, Martens, Victoria, Khosh-Naucke, Melissa, Gerull, Helwe, Müller, Jürgen, Behrmann, Lena, Blohm, Martin, Zahedi, René P., Jeremias, Irmela, Sickmann, Albert, Nollau, Peter, Horstmann, Martin A.
Publicado no Blood Adv (2018)

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

Por Ebinger, Sarah, Özdemir, Erbey Ziya, Ziegenhain, Christoph, Tiedt, Sebastian, Castro Alves, Catarina, Grunert, Michaela, Dworzak, Michael, Lutz, Christoph, Turati, Virginia A., Enver, Tariq, Horny, Hans-Peter, Sotlar, Karl, Parekh, Swati, Spiekermann, Karsten, Hiddemann, Wolfgang, Schepers, Aloys, Polzer, Bernhard, Kirsch, Stefan, Hoffmann, Martin, Knapp, Bettina, Hasenauer, Jan, Pfeifer, Heike, Panzer-Grümayer, Renate, Enard, Wolfgang, Gires, Olivier, Jeremias, Irmela
Publicado no Cancer Cell (2016)

Loss of KDM6A confers drug resistance in acute myeloid leukemia

Por Stief, Sophie M., Hanneforth, Anna-Li, Weser, Sabrina, Mattes, Raphael, Carlet, Michela, Liu, Wen-Hsin, Bartoschek, Michael D., Domínguez Moreno, Helena, Oettle, Matthias, Kempf, Julia, Vick, Binje, Ksienzyk, Bianka, Tizazu, Belay, Rothenberg-Thurley, Maja, Quentmeier, Hilmar, Hiddemann, Wolfgang, Vosberg, Sebastian, Greif, Philipp A., Metzeler, Klaus H., Schotta, Gunnar, Bultmann, Sebastian, Jeremias, Irmela, Leonhardt, Heinrich, Spiekermann, Karsten
Publicado no Leukemia (2019)