Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations

Effectively targeting leukemia-initiating cells (LIC) in FLT3-ITD-mutated acute myeloid leukemia (AML) is crucial for cure. Tyrosine kinase inhibitors (TKI) have limited impact as single agents, failing to eradicate LIC in the bone marrow. Using primary AML samples and a patient-derived xenograft mo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Garz, Anne-Kathrin, Wolf, Saskia, Grath, Sonja, Gaidzik, Verena, Habringer, Stefan, Vick, Binje, Rudelius, Martina, Ziegenhain, Christoph, Herold, Sylvia, Weickert, Marie-Theresa, Smets, Martha, Peschel, Christian, Oostendorp, Robert A.J., Bultmann, Sebastian, Jeremias, Irmela, Thiede, Christian, Döhner, Konstanze, Keller, Ulrich, Götze, Katharina S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752477/
https://ncbi.nlm.nih.gov/pubmed/29312564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21877
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