FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27(Kip1) in acute myeloid leukemia

P27(Kip1) (p27) can prevent cell proliferation by inactivating cyclin-dependent kinases. This function is impaired upon phosphorylation of p27 at tyrosine residue 88. We observed that FLT3 and FLT3-ITD can directly bind and selectively phosphorylate p27 on this residue. Inhibition of FLT3-ITD in cel...

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Publicat a:Haematologica
Autors principals: Peschel, Ines, Podmirseg, Silvio R., Taschler, Martin, Duyster, Justus, Götze, Katharina S., Sill, Heinz, Nachbaur, David, Jäkel, Heidelinde, Hengst, Ludger
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541872/
https://ncbi.nlm.nih.gov/pubmed/28522571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.160101
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