Crenolanib is active against models of drug-resistant FLT3-ITD−positive acute myeloid leukemia

FLT3 kinase internal tandem duplication (ITD) mutations are common in acute myeloid leukemia (AML) and are associated with poor clinical outcomes. Although initial responses to FLT3 tyrosine kinase inhibitors (TKIs) are observed in FLT3-ITD−positive patients, subsequent relapse often occurs upon acq...

詳細記述

保存先:
書誌詳細
主要な著者: Zimmerman, Eric I., Turner, David C., Buaboonnam, Jassada, Hu, Shuiying, Orwick, Shelley, Roberts, Michael S., Janke, Laura J., Ramachandran, Abhijit, Stewart, Clinton F., Inaba, Hiroto, Baker, Sharyn D.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2013
主題:
Myeloid Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837509/
https://ncbi.nlm.nih.gov/pubmed/24046014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-07-513044
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