Crenolanib is active against models of drug-resistant FLT3-ITD−positive acute myeloid leukemia

FLT3 kinase internal tandem duplication (ITD) mutations are common in acute myeloid leukemia (AML) and are associated with poor clinical outcomes. Although initial responses to FLT3 tyrosine kinase inhibitors (TKIs) are observed in FLT3-ITD−positive patients, subsequent relapse often occurs upon acq...

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Bibliografiske detaljer
Main Authors: Zimmerman, Eric I., Turner, David C., Buaboonnam, Jassada, Hu, Shuiying, Orwick, Shelley, Roberts, Michael S., Janke, Laura J., Ramachandran, Abhijit, Stewart, Clinton F., Inaba, Hiroto, Baker, Sharyn D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2013
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837509/
https://ncbi.nlm.nih.gov/pubmed/24046014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-07-513044
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