The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis

Novel targets are needed for treatment of devastating diseases such as cancer. For decades, natural products have guided innovative therapies by addressing diverse pathways. Inspired by the potent cytotoxic bioactivity of myxobacterial vioprolides A–D, we performed in‐depth studies on their mode of...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Kirsch, Volker C., Orgler, Christina, Braig, Simone, Jeremias, Irmela, Auerbach, David, Müller, Rolf, Vollmar, Angelika M., Sieber, Stephan A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004033/
https://ncbi.nlm.nih.gov/pubmed/31658409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201911158
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