Loss of KDM6A confers drug resistance in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm resulting from the malignant transformation of myeloid progenitors. Despite intensive chemotherapy leading to initial treatment responses, relapse caused by intrinsic or acquired drug resistance represents a major challenge. Here, we...

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Publicado no:Leukemia
Main Authors: Stief, Sophie M., Hanneforth, Anna-Li, Weser, Sabrina, Mattes, Raphael, Carlet, Michela, Liu, Wen-Hsin, Bartoschek, Michael D., Domínguez Moreno, Helena, Oettle, Matthias, Kempf, Julia, Vick, Binje, Ksienzyk, Bianka, Tizazu, Belay, Rothenberg-Thurley, Maja, Quentmeier, Hilmar, Hiddemann, Wolfgang, Vosberg, Sebastian, Greif, Philipp A., Metzeler, Klaus H., Schotta, Gunnar, Bultmann, Sebastian, Jeremias, Irmela, Leonhardt, Heinrich, Spiekermann, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214274/
https://ncbi.nlm.nih.gov/pubmed/31201358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0497-6
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