Hematopoietic stem cells made BETter by inhibition

par Marando, Ludovica, Huntly, Brian J. P.
Publié dans Haematologica (2018)

Prognostic models turn the Heat(IT)up on FLT3(ITD)-mutated AML

par Gallipoli, Paolo, Huntly, Brian J.P.
Publié dans Clin Cancer Res (2018)

Molecular Landscape of Acute Myeloid Leukemia: Prognostic and Therapeutic Implications

par Marando, Ludovica, Huntly, Brian J. P.
Publié dans Curr Oncol Rep (2020)

Recent advances in acute myeloid leukemia stem cell biology

par Horton, Sarah J., Huntly, Brian J.P.
Publié 2012

Targeting Chromatin Regulation in Acute Myeloid Leukemia

par Richardson, Simon E., Huntly, Brian J. P.
Publié dans Hemasphere (2021)

Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia

par Gallipoli, Paolo, Giotopoulos, George, Huntly, Brian J.P.
Publié dans Ther Adv Hematol (2015)

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

par Grimwade, David, Ivey, Adam, Huntly, Brian J. P.
Publié dans Blood (2016)

Constitutively activated FGFR3 mutants signal through PLCγ-dependent and -independent pathways for hematopoietic transformation

par Chen, Jing, Williams, Ifor R., Lee, Benjamin H., Duclos, Nicole, Huntly, Brian J. P., Donoghue, Daniel J., Gilliland, D. Gary
Publié 2005

The Transcriptional Coactivator Cbp Regulates Self-Renewal and Differentiation in Adult Hematopoietic Stem Cells

par Chan, Wai-In, Hannah, Rebecca L., Dawson, Mark A., Pridans, Clare, Foster, Donna, Joshi, Anagha, Göttgens, Berthold, Van Deursen, Jan M., Huntly, Brian J. P.
Publié 2011

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis

par Scholl, Claudia, Bansal, Dimple, Döhner, Konstanze, Eiwen, Karina, Huntly, Brian J.P., Lee, Benjamin H., Rücker, Frank G., Schlenk, Richard F., Bullinger, Lars, Döhner, Hartmut, Gilliland, D. Gary, Fröhling, Stefan
Publié 2007

Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model

par Bansal, Dimple, Scholl, Claudia, Fröhling, Stefan, McDowell, Elizabeth, Lee, Benjamin H., Döhner, Konstanze, Ernst, Patricia, Davidson, Alan J., Daley, George Q., Zon, Leonard I., Gilliland, D. Gary, Huntly, Brian J. P.
Publié 2006

The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors

par Pellicano, Francesca, Scott, Mary T, Helgason, G Vignir, Hopcroft, Lisa E M, Allan, Elaine K, Aspinall-O'Dea, Mark, Copland, Mhairi, Pierce, Andrew, Huntly, Brian J P, Whetton, Anthony D, Holyoake, Tessa L
Publié dans Stem Cells (2014)

Core outcome set measurement for future clinical trials in acute myeloid leukemia: the HARMONY study protocol using a multi-stakeholder consensus-based Delphi process and a final c...

par Lang, Katharina M., Harrison, Kathryn L., Williamson, Paula R., Huntly, Brian J. P., Ossenkoppele, Gert, Geissler, Jan, Bereczky, Tamàs, Hernández-Rivas, Jesús M., Chevrou-Séverac, Hélène, Goodbody, Rory, Schulze-Rath, Renate, Bullinger, Lars
Publié dans Trials (2020)

KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements

par Au, Yan Zi, Gu, Muxin, De Braekeleer, Etienne, Gozdecka, Malgorzata, Aspris, Demetrios, Tarumoto, Yusuke, Cooper, Jonathan, Yu, Jason, Ong, Swee Hoe, Chen, Xi, Tzelepis, Konstantinos, Huntly, Brian J.P, Vassiliou, George, Yusa, Kosuke
Publié dans Leukemia (2021)

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

par Basilico, Silvia, Wang, Xiaonan, Kennedy, Alison, Tzelepis, Konstantinos, Giotopoulos, George, Kinston, Sarah J., Quiros, Pedro M., Wong, Kim, Adams, David J., Carnevalli, Larissa S., Huntly, Brian J. P., Vassiliou, George S., Calero-Nieto, Fernando J., Göttgens, Berthold
Publié dans Nat Commun (2020)

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia

par Lee, Benjamin H., Tothova, Zuzana, Levine, Ross L., Anderson, Kristina, Buza-Vidas, Natalija, Cullen, Dana E., McDowell, Elizabeth P., Adelsperger, Jennifer, Fröhling, Stefan, Huntly, Brian J.P., Beran, Miloslav, Jacobsen, Sten Eirik, Gilliland, D. Gary
Publié 2007

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

par Sasca, Daniel, Yun, Haiyang, Giotopoulos, George, Szybinski, Jakub, Evan, Theo, Wilson, Nicola K., Gerstung, Moritz, Gallipoli, Paolo, Green, Anthony R., Hills, Robert, Russell, Nigel, Osborne, Cameron S., Papaemmanuil, Elli, Göttgens, Berthold, Campbell, Peter, Huntly, Brian J. P.
Publié dans Blood (2019)

Glutaminolysis is a metabolic dependency in FLT3(ITD) acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

par Gallipoli, Paolo, Giotopoulos, George, Tzelepis, Konstantinos, Costa, Ana S.H., Vohra, Shabana, Medina-Perez, Paula, Basheer, Faisal, Marando, Ludovica, Di Lisio, Lorena, Dias, Joao M. L., Yun, Haiyang, Sasca, Daniel, Horton, Sarah J., Vassiliou, George, Frezza, Christian, Huntly, Brian J.P.
Publié dans Blood (2018)

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia

par Li, Juan, Spensberger, Dominik, Ahn, Jong Sook, Anand, Shubha, Beer, Philip A., Ghevaert, Cedric, Chen, Edwin, Forrai, Ariel, Scott, Linda M., Ferreira, Rita, Campbell, Peter J., Watson, Steve P., Liu, Pentao, Erber, Wendy N., Huntly, Brian J. P., Ottersbach, Katrin, Green, Anthony R.
Publié 2010

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

par Giotopoulos, George, van der Weyden, Louise, Osaki, Hikari, Rust, Alistair G., Gallipoli, Paolo, Meduri, Eshwar, Horton, Sarah J., Chan, Wai-In, Foster, Donna, Prinjha, Rab K., Pimanda, John E., Tenen, Daniel G., Vassiliou, George S., Koschmieder, Steffen, Adams, David J., Huntly, Brian J.P.
Publié dans J Exp Med (2015)