Glutaminolysis is a metabolic dependency in FLT3(ITD) acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

FLT3 internal tandem duplication (FLT3(ITD)) are common mutations in acute myeloid leukemia (AML) associated with poor patient prognosis. Although new generation FLT3 tyrosine kinase inhibitors (TKI) have shown promising results, the outcome of FLT3(ITD) AML patients remains poor and demands the ide...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Blood
Hlavní autoři: Gallipoli, Paolo, Giotopoulos, George, Tzelepis, Konstantinos, Costa, Ana S.H., Vohra, Shabana, Medina-Perez, Paula, Basheer, Faisal, Marando, Ludovica, Di Lisio, Lorena, Dias, Joao M. L., Yun, Haiyang, Sasca, Daniel, Horton, Sarah J., Vassiliou, George, Frezza, Christian, Huntly, Brian J.P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061932/
https://ncbi.nlm.nih.gov/pubmed/29463564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-12-820035
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky