Hemophagocytic Syndrome and Critical Illness: New insights into Diagnosis and Management

Por Tothova, Zuzana, Berliner, Nancy
Publicado em 2014

New Strategies in Myelodysplastic Syndromes: Application of molecular diagnostics to clinical practice

Por Tothova, Zuzana, Steensma, David P., Ebert, Benjamin L.
Publicado em 2013

Intergenerational epigenetic inheritance of cancer susceptibility in mammals

Por Lesch, Bluma J, Tothova, Zuzana, Morgan, Elizabeth A, Liao, Zhicong, Bronson, Roderick T, Ebert, Benjamin L, Page, David C
Publicado no eLife (2019)

mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion

Por Lee, Jae Y., Nakada, Daisuke, Yilmaz, Omer H., Tothova, Zuzana, Joseph, Nancy M., Lim, Megan S., Gilliland, D. Gary, Morrison, Sean J.
Publicado em 2010

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation

Por Doench, John G., Hartenian, Ella, Graham, Daniel B., Tothova, Zuzana, Hegde, Mudra, Smith, Ian, Sullender, Meagan, Ebert, Benjamin L., Xavier, Ramnik J., Root, David E.
Publicado no Nat Biotechnol (2014)

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses

Por Masutomi, Kenkichi, Possemato, Richard, Wong, Judy M. Y., Currier, Jennifer L., Tothova, Zuzana, Manola, Judith B., Ganesan, Shridar, Lansdorp, Peter M., Collins, Kathleen, Hahn, William C.
Publicado em 2005

Multiplex CRISPR-Cas9 Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia

Por Tothova, Zuzana, Krill-Burger, John M., Popova, Katerina D., Landers, Catherine C., Sievers, Quinlan L., Yudovich, David, Belizaire, Roger, Aster, Jon C., Morgan, Elizabeth A., Tsherniak, Aviad, Ebert, Benjamin L.
Publicado no Cell Stem Cell (2017)

An Assessment of the Effect of Green Synthesized Silver Nanoparticles Using Sage Leaves (Salvia officinalis L.) on Germinated Plants of Maize (Zea mays L.)

Por Sehnal, Karel, Hosnedlova, Bozena, Docekalova, Michaela, Stankova, Martina, Uhlirova, Dagmar, Tothova, Zuzana, Kepinska, Marta, Milnerowicz, Halina, Fernandez, Carlos, Ruttkay-Nedecky, Branislav, Nguyen, Hoai Viet, Ofomaja, Augustine, Sochor, Jiri, Kizek, Rene
Publicado no Nanomaterials (Basel) (2019)

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

Por Doench, John G., Fusi, Nicolo, Sullender, Meagan, Hegde, Mudra, Vaimberg, Emma W., Donovan, Katherine F., Smith, Ian, Tothova, Zuzana, Wilen, Craig, Orchard, Robert, Virgin, Herbert W., Listgarten, Jennifer, Root, David E.
Publicado no Nat Biotechnol (2016)

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia

Por Lee, Benjamin H., Tothova, Zuzana, Levine, Ross L., Anderson, Kristina, Buza-Vidas, Natalija, Cullen, Dana E., McDowell, Elizabeth P., Adelsperger, Jennifer, Fröhling, Stefan, Huntly, Brian J.P., Beran, Miloslav, Jacobsen, Sten Eirik, Gilliland, D. Gary
Publicado em 2007

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification

Por Cornejo, Melanie G., Mabialah, Vinciane, Sykes, Stephen M., Khandan, Tulasi, Lo Celso, Cristina, Lopez, Cécile K., Rivera-Muñoz, Paola, Rameau, Philippe, Tothova, Zuzana, Aster, Jon C., DePinho, Ronald A., Scadden, David T., Gilliland, D. Gary, Mercher, Thomas
Publicado em 2011

Mutant calreticulin requires both its mutant C-terminus and the thrombopoietin receptor for oncogenic transformation

Por Elf, Shannon, Abdelfattah, Nouran S., Chen, Edwin, Perales-Patón, Javier, Rosen, Emily A., Ko, Amy, Peisker, Fabian, Florescu, Natalie, Giannini, Silvia, Wolach, Ofir, Morgan, Elizabeth A., Tothova, Zuzana, Losman, Julie-Aurore, Schneider, Rebekka K., Al-Shahrour, Fatima, Mullally, Ann
Publicado no Cancer Discov (2016)

FoxOs are lineage-restricted redundant tumor suppressors and critical regulators of endothelial cell homeostasis

Por Paik, Ji-Hye, Kollipara, Ramya, Chu, Gerald, Ji, Hongkai, Xiao, Yonghong, Ding, Zhihu, Miao, Lili, Tothova, Zuzana, Horner, James W., Carrasco, Daniel R., Jiang, Shan, Gilliland, D. Gary, Chin, Lynda, Wong, Wing H., Castrillon, Diego H., DePinho, Ronald A.
Publicado em 2007

AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

Por Sykes, Stephen M., Lane, Steven W., Bullinger, Lars, Kalaitzidis, Demetrios, Yusuf, Rushdia, Saez, Borja, Ferraro, Francesca, Mercier, Francois, Singh, Harshabad, Brumme, Kristina M., Acharya, Sanket S., Scholl, Claudia, Tothova, Zuzana, Attar, Eyal C., Fröhling, Stefan, DePinho, Ronald A., Gilliland, D. Gary, Armstrong, Scott A., Scadden, David T.
Publicado em 2011

Core circadian clock genes regulate leukemia stem cells in AML

Por Puram, Rishi V., Kowalczyk, Monika S., de Boer, Carl G., Schneider, Rebekka K., Miller, Peter G., McConkey, Marie, Tothova, Zuzana, Tejero, Héctor, Heckl, Dirk, Järås, Marcus, Chen, Michelle C., Li, Hubo, Tamayo, Alfred, Cowley, Glenn S., Rozenblatt-Rosen, Orit, Al-Shahrour, Fatima, Regev, Aviv, Ebert, Benjamin L.
Publicado no Cell (2016)

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

Por Hartwell, Kimberly A, Miller, Peter G, Mukherjee, Siddhartha, Kahn, Alissa R, Stewart, Alison L, Logan, David J, Negri, Joseph M, Duvet, Mildred, Järås, Marcus, Puram, Rishi, Dancik, Vlado, Al-Shahrour, Fatima, Kindler, Thomas, Tothova, Zuzana, Chattopadhyay, Shrikanta, Hasaka, Thomas, Narayan, Rajiv, Dai, Mingji, Huang, Christina, Shterental, Sebastian, Chu, Lisa P, Haydu, J Erika, Shieh, Jae Hung, Steensma, David P, Munoz, Benito, Bittker, Joshua A, Shamji, Alykhan F, Clemons, Paul A, Tolliday, Nicola J, Carpenter, Anne E, Gilliland, D Gary, Stern, Andrew M, Moore, Malcolm A S, Scadden, David T, Schreiber, Stuart L, Ebert, Benjamin L, Golub, Todd R
Publicado em 2013