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mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion
Pten deficiency depletes hematopoietic stem cells (HSCs) but expands leukemia-initiating cells and the mTOR inhibitor, rapamycin, blocks these effects. Understanding the opposite effects of mTOR activation on HSCs versus leukemia-initiating cells could improve anti-leukemia therapies. We found that...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995996/ https://ncbi.nlm.nih.gov/pubmed/21040901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.09.015 |
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