AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor

The regulation of the subcellular localization of phosphatase and tensin homologue (PTEN) is critical to its tumor-suppressing functions. Previously, we found that the activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR/S6 protein kinase (S6K) cascade triggers the nuclear export of PTEN duri...

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Detaylı Bibliyografya
Asıl Yazarlar: Liu, Juinn-Lin, Mao, Zhenyu, Gallick, Gary E., Yung, W. K. Alfred
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2011
Konular:
Basic and Translational Investigations
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064623/
https://ncbi.nlm.nih.gov/pubmed/21123367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq163
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