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GLUT1 enhances mTOR activity independently of TSC2 and AMPK

Enhanced GLUT1 expression in mesangial cells plays an important role in the development of diabetic nephropathy by stimulating signaling through several pathways resulting in increased glomerular matrix accumulation. Similarly, enhanced mammalian target of rapamycin (mTOR) activation has been implic...

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Detalhes bibliográficos
Main Authors: Buller, Carolyn L., Heilig, Charles W., Brosius, Frank C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174561/
https://ncbi.nlm.nih.gov/pubmed/21613414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00472.2010
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