Mutant calreticulin requires both its mutant C-terminus and the thrombopoietin receptor for oncogenic transformation

Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN) but the mechanism by which mutant CALR is oncogenic remains unclear. Here, we demonstrate that expression of mutant CALR alone is sufficient to engender MPN in mice and recap...

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Publicat a:Cancer Discov
Autors principals: Elf, Shannon, Abdelfattah, Nouran S., Chen, Edwin, Perales-Patón, Javier, Rosen, Emily A., Ko, Amy, Peisker, Fabian, Florescu, Natalie, Giannini, Silvia, Wolach, Ofir, Morgan, Elizabeth A., Tothova, Zuzana, Losman, Julie-Aurore, Schneider, Rebekka K., Al-Shahrour, Fatima, Mullally, Ann
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851866/
https://ncbi.nlm.nih.gov/pubmed/26951227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1434
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