Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN

Mutations in calreticulin (CALR) are phenotypic drivers in the pathogenesis of myeloproliferative neoplasms. Mechanistic studies have demonstrated that mutant CALR binds to the thrombopoietin receptor MPL, and that the positive electrostatic charge of the mutant CALR C terminus is required for mutan...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Elf, Shannon, Abdelfattah, Nouran S., Baral, April J., Beeson, Danielle, Rivera, Jeanne F., Ko, Amy, Florescu, Natalie, Birrane, Gabriel, Chen, Edwin, Mullally, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814933/
https://ncbi.nlm.nih.gov/pubmed/29288169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-08-800896
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