Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN

Mutations in calreticulin (CALR) are phenotypic drivers in the pathogenesis of myeloproliferative neoplasms. Mechanistic studies have demonstrated that mutant CALR binds to the thrombopoietin receptor MPL, and that the positive electrostatic charge of the mutant CALR C terminus is required for mutan...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Elf, Shannon, Abdelfattah, Nouran S., Baral, April J., Beeson, Danielle, Rivera, Jeanne F., Ko, Amy, Florescu, Natalie, Birrane, Gabriel, Chen, Edwin, Mullally, Ann
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2018
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814933/
https://ncbi.nlm.nih.gov/pubmed/29288169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-08-800896
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