Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN

Mutations in calreticulin (CALR) are phenotypic drivers in the pathogenesis of myeloproliferative neoplasms. Mechanistic studies have demonstrated that mutant CALR binds to the thrombopoietin receptor MPL, and that the positive electrostatic charge of the mutant CALR C terminus is required for mutan...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Blood
Autors principals: Elf, Shannon, Abdelfattah, Nouran S., Baral, April J., Beeson, Danielle, Rivera, Jeanne F., Ko, Amy, Florescu, Natalie, Birrane, Gabriel, Chen, Edwin, Mullally, Ann
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2018
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814933/
https://ncbi.nlm.nih.gov/pubmed/29288169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-08-800896
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars