NPM1 mutations define a specific subgroup of MDS and MDS/MPN patients with favorable outcomes with intensive chemotherapy

Nucleophosmin (NPM1) mutations are common in acute myeloid leukemia and are associated with high remission rates and prolonged survival with intensive chemotherapy. NPM1 mutations are rare in myelodysplastic syndromes (MDS) or myelodysplastic/myeloproliferative neoplasm (MDS/MPN), and the clinical o...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Montalban-Bravo, Guillermo, Kanagal-Shamanna, Rashmi, Sasaki, Koji, Patel, Keyur, Ganan-Gomez, Irene, Jabbour, Elias, Kadia, Tapan, Ravandi, Farhad, DiNardo, Courtney, Borthakur, Gautham, Takahashi, Koichi, Konopleva, Marina, Komrokji, Rami S., DeZern, Amy, Kuzmanovic, Teodora, Maciejewski, Jaroslaw, Pierce, Sherry, Colla, Simona, Sekeres, Mikkael A., Kantarjian, Hagop, Bueso-Ramos, Carlos, Garcia-Manero, Guillermo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436014/
https://ncbi.nlm.nih.gov/pubmed/30902805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018026989
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