NPM1 mutations define a specific subgroup of MDS and MDS/MPN patients with favorable outcomes with intensive chemotherapy

Nucleophosmin (NPM1) mutations are common in acute myeloid leukemia and are associated with high remission rates and prolonged survival with intensive chemotherapy. NPM1 mutations are rare in myelodysplastic syndromes (MDS) or myelodysplastic/myeloproliferative neoplasm (MDS/MPN), and the clinical o...

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Bibliographic Details
Published in:Blood Adv
Main Authors: Montalban-Bravo, Guillermo, Kanagal-Shamanna, Rashmi, Sasaki, Koji, Patel, Keyur, Ganan-Gomez, Irene, Jabbour, Elias, Kadia, Tapan, Ravandi, Farhad, DiNardo, Courtney, Borthakur, Gautham, Takahashi, Koichi, Konopleva, Marina, Komrokji, Rami S., DeZern, Amy, Kuzmanovic, Teodora, Maciejewski, Jaroslaw, Pierce, Sherry, Colla, Simona, Sekeres, Mikkael A., Kantarjian, Hagop, Bueso-Ramos, Carlos, Garcia-Manero, Guillermo
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2019
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436014/
https://ncbi.nlm.nih.gov/pubmed/30902805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018026989
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