Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN

Mutations in calreticulin (CALR) are phenotypic drivers in the pathogenesis of myeloproliferative neoplasms. Mechanistic studies have demonstrated that mutant CALR binds to the thrombopoietin receptor MPL, and that the positive electrostatic charge of the mutant CALR C terminus is required for mutan...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Elf, Shannon, Abdelfattah, Nouran S., Baral, April J., Beeson, Danielle, Rivera, Jeanne F., Ko, Amy, Florescu, Natalie, Birrane, Gabriel, Chen, Edwin, Mullally, Ann
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814933/
https://ncbi.nlm.nih.gov/pubmed/29288169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-08-800896
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