Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis

Calreticulin (CALR) is mutated in the majority of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs). Mutant CALR (CALR(del52)) exerts its effect by binding to the thrombopoietin receptor MPL to cause constitutive activation of JAK-STAT signaling. In this study, we performed an extensive mutagen...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood Adv
Egile Nagusiak: Rivera, Jeanne F., Baral, April J., Nadat, Fatima, Boyd, Grace, Smyth, Rachael, Patel, Hershna, Burman, Emma L., Alameer, Ghadah, Boxall, Sally A., Jackson, Brian R., Baxter, E. Joanna, Laslo, Peter, Green, Anthony R., Kent, David G., Mullally, Ann, Chen, Edwin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2021
Gaiak:
Myeloid Neoplasia
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045488/
https://ncbi.nlm.nih.gov/pubmed/33821991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002402
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