Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis

Calreticulin (CALR) is mutated in the majority of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs). Mutant CALR (CALR(del52)) exerts its effect by binding to the thrombopoietin receptor MPL to cause constitutive activation of JAK-STAT signaling. In this study, we performed an extensive mutagen...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Rivera, Jeanne F., Baral, April J., Nadat, Fatima, Boyd, Grace, Smyth, Rachael, Patel, Hershna, Burman, Emma L., Alameer, Ghadah, Boxall, Sally A., Jackson, Brian R., Baxter, E. Joanna, Laslo, Peter, Green, Anthony R., Kent, David G., Mullally, Ann, Chen, Edwin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045488/
https://ncbi.nlm.nih.gov/pubmed/33821991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002402
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