Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis

Calreticulin (CALR) is mutated in the majority of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs). Mutant CALR (CALR(del52)) exerts its effect by binding to the thrombopoietin receptor MPL to cause constitutive activation of JAK-STAT signaling. In this study, we performed an extensive mutagen...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood Adv
Auteurs principaux: Rivera, Jeanne F., Baral, April J., Nadat, Fatima, Boyd, Grace, Smyth, Rachael, Patel, Hershna, Burman, Emma L., Alameer, Ghadah, Boxall, Sally A., Jackson, Brian R., Baxter, E. Joanna, Laslo, Peter, Green, Anthony R., Kent, David G., Mullally, Ann, Chen, Edwin
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2021
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045488/
https://ncbi.nlm.nih.gov/pubmed/33821991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002402
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