The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms

The 46/1 JAK2 haplotype predisposes to V617F-positive myeloproliferative neoplasms, but the underlying mechanism is obscure. We analyzed essential thrombocythemia patients entered into the PT-1 studies and, as expected, found that 46/1 was overrepresented in V617F-positive cases (n = 404) versus con...

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Détails bibliographiques
Auteurs principaux: Jones, Amy V., Campbell, Peter J., Beer, Philip A., Schnittger, Susanne, Vannucchi, Alessandro M., Zoi, Katerina, Percy, Melanie J., McMullin, Mary Frances, Scott, Linda M., Tapper, William, Silver, Richard T., Oscier, David, Harrison, Claire N., Grallert, Harald, Kisialiou, Aliaksei, Strike, Paul, Chase, Andrew J., Green, Anthony R., Cross, Nicholas C. P.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2010
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145114/
https://ncbi.nlm.nih.gov/pubmed/20304805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-236448
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