The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms

The 46/1 JAK2 haplotype predisposes to V617F-positive myeloproliferative neoplasms, but the underlying mechanism is obscure. We analyzed essential thrombocythemia patients entered into the PT-1 studies and, as expected, found that 46/1 was overrepresented in V617F-positive cases (n = 404) versus con...

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Главные авторы: Jones, Amy V., Campbell, Peter J., Beer, Philip A., Schnittger, Susanne, Vannucchi, Alessandro M., Zoi, Katerina, Percy, Melanie J., McMullin, Mary Frances, Scott, Linda M., Tapper, William, Silver, Richard T., Oscier, David, Harrison, Claire N., Grallert, Harald, Kisialiou, Aliaksei, Strike, Paul, Chase, Andrew J., Green, Anthony R., Cross, Nicholas C. P.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2010
Предметы:
Myeloid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145114/
https://ncbi.nlm.nih.gov/pubmed/20304805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-236448
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