Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms

Somatic activating mutations in MPL, the thrombopoietin receptor, occur in the myeloproliferative neoplasms, although virtually nothing is known about their role in evolution to acute myeloid leukemia. In this study, the MPL T487A mutation, identified in de novo acute myeloid leukemia, was not detec...

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Bibliographische Detailangaben
Hauptverfasser: Beer, Philip A., Ortmann, Christina A., Stegelmann, Frank, Guglielmelli, Paola, Reilly, John T., Larsen, Thomas S., Hasselbalch, Hans C., Vannucchi, Alessandro M., Möller, Peter, Döhner, Konstanze, Green, Anthony R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2010
Schlagworte:
Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995575/
https://ncbi.nlm.nih.gov/pubmed/20823136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.029306
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