Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genom...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Tapper, William, Jones, Amy V., Kralovics, Robert, Harutyunyan, Ashot S., Zoi, Katerina, Leung, William, Godfrey, Anna L., Guglielmelli, Paola, Callaway, Alison, Ward, Daniel, Aranaz, Paula, White, Helen E., Waghorn, Katherine, Lin, Feng, Chase, Andrew, Joanna Baxter, E., Maclean, Cathy, Nangalia, Jyoti, Chen, Edwin, Evans, Paul, Short, Michael, Jack, Andrew, Wallis, Louise, Oscier, David, Duncombe, Andrew S., Schuh, Anna, Mead, Adam J., Griffiths, Michael, Ewing, Joanne, Gale, Rosemary E., Schnittger, Susanne, Haferlach, Torsten, Stegelmann, Frank, Döhner, Konstanze, Grallert, Harald, Strauch, Konstantin, Tanaka, Toshiko, Bandinelli, Stefania, Giannopoulos, Andreas, Pieri, Lisa, Mannarelli, Carmela, Gisslinger, Heinz, Barosi, Giovanni, Cazzola, Mario, Reiter, Andreas, Harrison, Claire, Campbell, Peter, Green, Anthony R., Vannucchi, Alessandro, Cross, Nicholas C.P.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396373/
https://ncbi.nlm.nih.gov/pubmed/25849990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7691
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires