The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms

The 46/1 JAK2 haplotype predisposes to V617F-positive myeloproliferative neoplasms, but the underlying mechanism is obscure. We analyzed essential thrombocythemia patients entered into the PT-1 studies and, as expected, found that 46/1 was overrepresented in V617F-positive cases (n = 404) versus con...

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Autori principali: Jones, Amy V., Campbell, Peter J., Beer, Philip A., Schnittger, Susanne, Vannucchi, Alessandro M., Zoi, Katerina, Percy, Melanie J., McMullin, Mary Frances, Scott, Linda M., Tapper, William, Silver, Richard T., Oscier, David, Harrison, Claire N., Grallert, Harald, Kisialiou, Aliaksei, Strike, Paul, Chase, Andrew J., Green, Anthony R., Cross, Nicholas C. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145114/
https://ncbi.nlm.nih.gov/pubmed/20304805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-236448
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