Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis

Calreticulin (CALR) is mutated in the majority of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs). Mutant CALR (CALR(del52)) exerts its effect by binding to the thrombopoietin receptor MPL to cause constitutive activation of JAK-STAT signaling. In this study, we performed an extensive mutagen...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Rivera, Jeanne F., Baral, April J., Nadat, Fatima, Boyd, Grace, Smyth, Rachael, Patel, Hershna, Burman, Emma L., Alameer, Ghadah, Boxall, Sally A., Jackson, Brian R., Baxter, E. Joanna, Laslo, Peter, Green, Anthony R., Kent, David G., Mullally, Ann, Chen, Edwin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2021
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045488/
https://ncbi.nlm.nih.gov/pubmed/33821991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002402
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