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Mutant calreticulin in myeloproliferative neoplasms
Recurrent mutations in calreticulin are present in ∼20% of patients with myeloproliferative neoplasms (MPNs). Since its discovery in 2013, we now have a more precise understanding of how mutant CALR, an endoplasmic reticulum chaperone protein, activates the JAK/STAT signaling pathway via a pathogeni...
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| Pubblicato in: | Blood |
|---|---|
| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6923668/ https://ncbi.nlm.nih.gov/pubmed/31562135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000622 |
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