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Mechanism underlying the development of myeloproliferative neoplasms through mutant calreticulin

Deregulation of cytokine signaling is frequently associated with various pathological conditions, including malignancies. In patients with myeloproliferative neoplasms (MPNs), recurrent somatic mutations in the calreticulin (CALR) gene, which encodes a molecular chaperone that resides in the endopla...

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Detalles Bibliográficos
Publicado en:Cancer Sci
Main Authors: Edahiro, Yoko, Araki, Marito, Komatsu, Norio
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419020/
https://ncbi.nlm.nih.gov/pubmed/32462673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14503
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