High-Throughput RT-PCR for small-molecule screening assays

le Bittker, Joshua A.
Foilsithe 2012

Nucleic acid evolution and minimization by nonhomologous random recombination

le Bittker, Joshua A., Le, Brian V., Liu, David R.
Foilsithe 2002

Directed evolution of protein enzymes using nonhomologous random recombination

le Bittker, Joshua A., Le, Brian V., Liu, Jane M., Liu, David R.
Foilsithe 2004

Enhancing the rate of scaffold discovery with diversity-oriented prioritization

le Swamidass, S. Joshua, Calhoun, Bradley T., Bittker, Joshua A., Bodycombe, Nicole E., Clemons, Paul A.
Foilsithe 2011

Utility-Aware Screening with Clique-Oriented Prioritization

le Swamidass, S. Joshua, Calhoun, Bradley T., Bittker, Joshua A., Bodycombe, Nicole E., Clemons, Paul A.
Foilsithe 2011

An Economic Framework to Prioritize Confirmatory Tests Following a High-Throughput Screen

le Swamidass, S. Joshua, Bittker, Joshua A., Bodycombe, Nicole E., Ryder, Sean P., Clemons, Paul A.
Foilsithe 2010

Disrupting fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

le Youngsaye, Willmen, Dockendorff, Chris, Vincent, Benjamin, Hartland, Cathy L., Bittker, Joshua A., Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L., Munoz, Benito
Foilsithe 2012

Small-molecule inducers of insulin expression in pancreatic α-cells

le Fomina-Yadlin, Dina, Kubicek, Stefan, Walpita, Deepika, Dančik, Vlado, Hecksher-Sørensen, Jacob, Bittker, Joshua A., Sharifnia, Tanaz, Shamji, Alykhan, Clemons, Paul A., Wagner, Bridget K., Schreiber, Stuart L.
Foilsithe 2010

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

le Weïwer, Michel, Bittker, Joshua A., Lewis, Timothy A., Shimada, Kenichi, Yang, Wan Seok, MacPherson, Lawrence, Dandapani, Sivaraman, Palmer, Michelle, Stockwell, Brent R., Schreiber, Stuart L., Munoz, Benito
Foilsithe 2011

High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1/Bcl-2 Binding

le Chiang, Wei-Chung, Wei, Yongjie, Kuo, Yi-Chun, Wei, Shuguang, Zhou, Anwu, Zou, Zhongju, Yehl, Jenna, Ranaghan, Matthew J., Skepner, Adam, Bittker, Joshua A., Perez, Jose R, Posner, Bruce A., Levine, Beth
Foilsithe in ACS Chem Biol (2018)

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

le Youngsaye, Willmen, Vincent, Benjamin, Hartland, Cathy L., Morgan, Barbara J., Buhrlage, Sara J., Johnston, Stephen, Bittker, Joshua A., MacPherson, Lawrence, Dandapani, Sivaraman, Palmer, Michelle, Munoz, Benito, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L.
Foilsithe 2011

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

le Youngsaye, Willmen, Hartland, Cathy L, Morgan, Barbara J, Ting, Amal, Nag, Partha P, Vincent, Benjamin, Mosher, Carrie A, Bittker, Joshua A, Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L, Munoz, Benito
Foilsithe 2013

High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth

le Radke, Joshua B., Carey, Kimberly L., Shaw, Subrata, Metkar, Shailesh R., Mulrooney, Carol, Gale, Jennifer P., Bittker, Joshua A., Hilgraf, Robert, Comer, Eamon, Schreiber, Stuart L., Virgin, Herbert W., Perez, Jose R., Sibley, L. David
Foilsithe in ACS Infect Dis (2018)

The Drug Repurposing Hub: a next-generation drug library and information resource

le Corsello, Steven M., Bittker, Joshua A., Liu, Zihan, Gould, Joshua, McCarren, Patrick, Hirschman, Jodi E., Johnston, Stephen E., Vrcic, Anita, Wong, Bang, Khan, Mariya, Asiedu, Jacob, Narayan, Rajiv, Mader, Christopher C., Subramanian, Aravind, Golub, Todd R.
Foilsithe in Nat Med (2017)

Evolving BioAssay Ontology (BAO): modularization, integration and applications

le Abeyruwan, Saminda, Vempati, Uma D, Küçük-McGinty, Hande, Visser, Ubbo, Koleti, Amar, Mir, Ahsan, Sakurai, Kunie, Chung, Caty, Bittker, Joshua A, Clemons, Paul A, Brudz, Steve, Siripala, Anosha, Morales, Arturo J, Romacker, Martin, Twomey, David, Bureeva, Svetlana, Lemmon, Vance, Schürer, Stephan C
Foilsithe 2014

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

le Leshchiner, Elizaveta S., Rush, Jason S., Durney, Michael A., Cao, Zhifang, Dančík, Vlado, Chittick, Benjamin, Wu, Huixian, Petrone, Adam, Bittker, Joshua A., Phillips, Andrew, Perez, Jose R., Shamji, Alykhan F., Kaushik, Virendar K., Daly, Mark J., Graham, Daniel B., Schreiber, Stuart L., Xavier, Ramnik J.
Foilsithe in Proc Natl Acad Sci U S A (2017)

An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries

le Mulrooney, Carol A., Lahr, David L., Quintin, Michael J., Youngsaye, Willmen, Moccia, Dennis, Asiedu, Jacob K., Mulligan, Evan L., Akella, Lakshmi B., Marcaurelle, Lisa A., Montgomery, Philip, Bittker, Joshua A., Clemons, Paul A., Brudz, Stephen, Dandapani, Sivaraman, Duvall, Jeremy R., Tolliday, Nicola J., De Souza, Andrea
Foilsithe in J Comput Aided Mol Des (2013)

Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile

le Duvall, Jeremy R., Bedard, Leanne, Naylor-Olsen, Adel M., Manson, Abigail L., Bittker, Joshua A., Sun, Wenye, Fitzgerald, Mark E., He, Zhenmin, Lee, Maurice D., Marie, Jean-Charles, Muncipinto, Giovanni, Rush, Diane, Xu, Deming, Xu, Huisheng, Zhang, Mingliang, Earl, Ashlee M., Palmer, Michelle A., Foley, Michael A., Vacca, Joseph P., Scherer, Christina A.
Foilsithe in ACS Infect Dis (2017)

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

le Bray, Mark-Anthony, Gustafsdottir, Sigrun M, Rohban, Mohammad H, Singh, Shantanu, Ljosa, Vebjorn, Sokolnicki, Katherine L, Bittker, Joshua A, Bodycombe, Nicole E, Dančík, Vlado, Hasaka, Thomas P, Hon, Cindy S, Kemp, Melissa M, Li, Kejie, Walpita, Deepika, Wawer, Mathias J, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Shamji, Alykhan F, Carpenter, Anne E
Foilsithe in Gigascience (2017)

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes

le Sharabi, Kfir, Lin, Hua, Tavares, Clint D. J., Dominy, John E., Camporez, Joao Paulo, Perry, Rachel J., Schilling, Roger, Rines, Amy K., Lee, Jaemin, Hickey, Marc, Bennion, Melissa, Palmer, Michelle, Nag, Partha P., Bittker, Joshua A., Perez, José, Jedrychowski, Mark P., Ozcan, Umut, Gygi, Steve P., Kamenecka, Theodore M., Shulman, Gerald I., Schreiber, Stuart L., Griffin, Patrick R., Puigserver, Pere
Foilsithe in Cell (2017)