Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

The effectiveness of the potent antifungal drug fluconazole is being compromised by the rise of drug-resistant fungal pathogens. While inhibition of Hsp90 or calcineurin can reverse drug resistance in Candida, such inhibitors also impair the homologous human host protein and fungal-selective chemose...

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Autors principals: Youngsaye, Willmen, Vincent, Benjamin, Hartland, Cathy L., Morgan, Barbara J., Buhrlage, Sara J., Johnston, Stephen, Bittker, Joshua A., MacPherson, Lawrence, Dandapani, Sivaraman, Palmer, Michelle, Munoz, Benito, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287054/
https://ncbi.nlm.nih.gov/pubmed/21802942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.06.105
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