Diversity-Oriented Synthesis of 13- to 18-Membered Macrolactams via Ring-Closing Metathesis

Yazar: Dandapani, Sivaraman, Lowe, Jason T., Comer, Eamon, Marcaurelle, Lisa A.
Yayımlandı J Org Chem (2011)

Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles

Yazar: Comer, Eamon, Liu, Haibo, Joliton, Adrien, Clabaut, Alexandre, Johnson, Christopher, Akella, Lakshmi B., Marcaurelle, Lisa A.
Baskı/Yayın Bilgisi 2011

Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp(3))–H Arylation

Yazar: Maetani, Micah, Zoller, Jochen, Melillo, Bruno, Verho, Oscar, Kato, Nobutaka, Pu, Jun, Comer, Eamon, Schreiber, Stuart L.
Yayımlandı J Am Chem Soc (2017)

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intrac...

Yazar: Nühs, Andrea, De Rycker, Manu, Manthri, Sujatha, Comer, Eamon, Scherer, Christina A., Schreiber, Stuart L., Ioset, Jean-Robert, Gray, David W.
Yayımlandı PLoS Negl Trop Dis (2015)

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

Yazar: Sharma, Manmohan, Malhotra, Nipun, Yogavel, Manickam, Harlos, Karl, Melillo, Bruno, Comer, Eamon, Gonse, Arthur, Parvez, Suhel, Mitasev, Branko, Fang, Francis G., Schreiber, Stuart L., Sharma, Amit
Yayımlandı Nat Commun (2021)

Tetracyclines Modify Translation By Targeting Key Human rRNA Substructures

Yazar: Mortison, Jonathan D., Schenone, Monica, Myers, Jacob A., Zhang, Ziyang, Chen, Linfeng, Ciarlo, Christie, Comer, Eamon, Natchiar, S. Kundhavai, Carr, Steven A., Klaholz, Bruno P., Myers, Andrew G.
Yayımlandı Cell Chem Biol (2018)

Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression

Yazar: Nagiec, Marek M., Skepner, Adam P., Negri, Joseph, Eichhorn, Michelle, Kuperwasser, Nicolas, Comer, Eamon, Muncipinto, Giovanni, Subramanian, Aravind, Clish, Clary, Musunuru, Kiran, Duvall, Jeremy R., Foley, Michael, Perez, Jose R., Palmer, Michelle A. J.
Yayımlandı PLoS One (2015)

High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth

Yazar: Radke, Joshua B., Carey, Kimberly L., Shaw, Subrata, Metkar, Shailesh R., Mulrooney, Carol, Gale, Jennifer P., Bittker, Joshua A., Hilgraf, Robert, Comer, Eamon, Schreiber, Stuart L., Virgin, Herbert W., Perez, Jose R., Sibley, L. David
Yayımlandı ACS Infect Dis (2018)

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

Yazar: Krönke, Jan, Udeshi, Namrata D., Narla, Anupama, Grauman, Peter, Hurst, Slater N., McConkey, Marie, Svinkina, Tanya, Heckl, Dirk, Comer, Eamon, Li, Xiaoyu, Ciarlo, Christie, Hartman, Emily, Munshi, Nikhil, Schenone, Monica, Schreiber, Stuart L., Carr, Steven A., Ebert, Benjamin L.
Baskı/Yayın Bilgisi 2013

Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors

Yazar: Lukens, Amanda K., Heidebrecht, Richard W., Mulrooney, Carol, Beaudoin, Jennifer A., Comer, Eamon, Duvall, Jeremy R., Fitzgerald, Mark E., Masi, Daniela, Galinsky, Kevin, Scherer, Christina A., Palmer, Michelle, Munoz, Benito, Foley, Michael, Schreiber, Stuart L., Wiegand, Roger C., Wirth, Dyann F.
Yayımlandı J Infect Dis (2015)

Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells

Yazar: Nagiec, Marek M., Duvall, Jeremy R., Skepner, Adam P., Howe, Eleanor A., Bastien, Jessica, Comer, Eamon, Marie, Jean-Charles, Johnston, Stephen E., Negri, Joseph, Eichhorn, Michelle, Vantourout, Julien, Clish, Clary, Musunuru, Kiran, Foley, Michael, Perez, Jose R., Palmer, Michelle A. J.
Yayımlandı Medchemcomm (2018)

High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria

Yazar: Swann, Justine, Corey, Victoria, Scherer, Christina A., Kato, Nobutaka, Comer, Eamon, Maetani, Micah, Antonova-Koch, Yevgeniya, Reimer, Christin, Gagaring, Kerstin, Ibanez, Maureen, Plouffe, David, Zeeman, Anne-Marie, Kocken, Clemens H. M., McNamara, Case W., Schreiber, Stuart L., Campo, Brice, Winzeler, Elizabeth A., Meister, Stephan
Yayımlandı ACS Infect Dis (2016)

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission

Yazar: Plouffe, David M., Wree, Melanie, Du, Alan Y., Meister, Stephan, Li, Fengwu, Patra, Kailash, Lubar, Aristea, Okitsu, Shinji L., Flannery, Erika L., Kato, Nobutaka, Tanaseichuk, Olga, Comer, Eamon, Zhou, Bin, Kuhen, Kelli, Zhou, Yingyao, Leroy, Didier, Schreiber, Stuart L., Scherer, Christina A., Vinetz, Joseph, Winzeler, Elizabeth A.
Yayımlandı Cell Host Microbe (2016)

Diversity-Oriented Synthesis-Facilitated Medicinal Chemistry: Toward the Development of Novel Antimalarial Agents

Yazar: Comer, Eamon, Beaudoin, Jennifer A., Kato, Nobutaka, Fitzgerald, Mark E., Heidebrecht, Richard W., Lee, Maurice duPont, Masi, Daniela, Mercier, Marion, Mulrooney, Carol, Muncipinto, Giovanni, Rowley, Ann, Crespo-Llado, Keila, Serrano, Adelfa E., Lukens, Amanda K., Wiegand, Roger C., Wirth, Dyann F., Palmer, Michelle A., Foley, Michael A., Munoz, Benito, Scherer, Christina A., Duvall, Jeremy R., Schreiber, Stuart L.
Baskı/Yayın Bilgisi 2014

Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling

Yazar: Chou, Danny Hung-Chieh, Vetere, Amedeo, Choudhary, Amit, Scully, Stephen S., Schenone, Monica, Tang, Alicia, Gomez, Rachel, Burns, Sean M., Lundh, Morten, Vital, Tamara, Comer, Eamon, Faloon, Patrick W., Dančík, Vlado, Ciarlo, Christie, Paulk, Joshiawa, Dai, Mingji, Reddy, Clark, Sun, Hanshi, Young, Matthew, Donato, Nicholas, Jaffe, Jacob, Clemons, Paul A., Palmer, Michelle, Carr, Steven A., Schreiber, Stuart L., Wagner, Bridget K.
Yayımlandı J Am Chem Soc (2015)

An Aldol-based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Yazar: Marcaurelle, Lisa A., Comer, Eamon, Dandapani, Sivaraman, Duvall, Jeremy R., Gerard, Baudouin, Kesavan, Sarathy, Lee, Maurice D., Liu, Haibo, Lowe, Jason T., Marie, Jean-Charles, Mulrooney, Carol A., Pandya, Bhaumik A., Rowley, Ann, Ryba, Troy D., Suh, Byung-Chul, Wei, Jingqiang, Young, Damian W., Akella, Lakshmi B., Ross, Nathan T., Zhang, Yan-Ling, Fass, Daniel M., Reis, Surya A., Zhao, Wen-Ning, Haggarty, Stephen J., Palmer, Michelle, Foley, Michael A.
Baskı/Yayın Bilgisi 2010

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

Yazar: Heidebrecht, Richard W., Mulrooney, Carol, Austin, Christopher P., Barker, Robert H., Beaudoin, Jennifer A., Cheng, Ken Chih-Chien, Comer, Eamon, Dandapani, Sivaraman, Dick, Justin, Duvall, Jeremy R., Ekland, Eric H., Fidock, David A., Fitzgerald, Mark E., Foley, Michael, Guha, Rajarshi, Hinkson, Paul, Kramer, Martin, Lukens, Amanda K., Masi, Daniela, Marcaurelle, Lisa A., Su, Xin-Zhuan, Thomas, Craig J., Weïwer, Michel, Wiegand, Roger C., Wirth, Dyann, Xia, Menghang, Yuan, Jing, Zhao, Jinghua, Palmer, Michelle, Munoz, Benito, Schreiber, Stuart
Baskı/Yayın Bilgisi 2011

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Yazar: Kato, Nobutaka, Comer, Eamon, Sakata-Kato, Tomoyo, Sharma, Arvind, Sharma, Manmohan, Maetani, Micah, Bastien, Jessica, Brancucci, Nicolas M., Bittker, Joshua A., Corey, Victoria, Clarke, David, Derbyshire, Emily R., Dornan, Gillian L., Duffy, Sandra, Eckley, Sean, Itoe, Maurice A., Koolen, Karin M. J., Lewis, Timothy A., Lui, Ping S., Lukens, Amanda K., Lund, Emily, March, Sandra, Meibalan, Elamaran, Meier, Bennett C., McPhail, Jacob A., Mitasev, Branko, Moss, Eli L., Sayes, Morgane, Van Gessel, Yvonne, Wawer, Mathias J., Yoshinaga, Takashi, Zeeman, Anne-Marie, Avery, Vicky M., Bhatia, Sangeeta N., Burke, John E., Catteruccia, Flaminia, Clardy, Jon C., Clemons, Paul A., Dechering, Koen J., Duvall, Jeremy R., Foley, Michael A., Gusovsky, Fabian, Kocken, Clemens H. M., Marti, Matthias, Morningstar, Marshall L., Munoz, Benito, Neafsey, Daniel E., Sharma, Amit, Winzeler, Elizabeth A., Wirth, Dyann F., Scherer, Christina A., Schreiber, Stuart L.
Yayımlandı Nature (2016)