Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling

Phenotypic cell-based screening is a powerful approach to small-molecule discovery, but a major challenge of this strategy lies in determining the intracellular target and mechanism of action (MoA) for validated hits. Here, we show that the small-molecule BRD0476, a novel suppressor of pancreatic β-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Chou, Danny Hung-Chieh, Vetere, Amedeo, Choudhary, Amit, Scully, Stephen S., Schenone, Monica, Tang, Alicia, Gomez, Rachel, Burns, Sean M., Lundh, Morten, Vital, Tamara, Comer, Eamon, Faloon, Patrick W., Dančík, Vlado, Ciarlo, Christie, Paulk, Joshiawa, Dai, Mingji, Reddy, Clark, Sun, Hanshi, Young, Matthew, Donato, Nicholas, Jaffe, Jacob, Clemons, Paul A., Palmer, Michelle, Carr, Steven A., Schreiber, Stuart L., Wagner, Bridget K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003570/
https://ncbi.nlm.nih.gov/pubmed/26042473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04284
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