Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling

Phenotypic cell-based screening is a powerful approach to small-molecule discovery, but a major challenge of this strategy lies in determining the intracellular target and mechanism of action (MoA) for validated hits. Here, we show that the small-molecule BRD0476, a novel suppressor of pancreatic β-...

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Publicado en:J Am Chem Soc
Autores principales: Chou, Danny Hung-Chieh, Vetere, Amedeo, Choudhary, Amit, Scully, Stephen S., Schenone, Monica, Tang, Alicia, Gomez, Rachel, Burns, Sean M., Lundh, Morten, Vital, Tamara, Comer, Eamon, Faloon, Patrick W., Dančík, Vlado, Ciarlo, Christie, Paulk, Joshiawa, Dai, Mingji, Reddy, Clark, Sun, Hanshi, Young, Matthew, Donato, Nicholas, Jaffe, Jacob, Clemons, Paul A., Palmer, Michelle, Carr, Steven A., Schreiber, Stuart L., Wagner, Bridget K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003570/
https://ncbi.nlm.nih.gov/pubmed/26042473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04284
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