Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling

Phenotypic cell-based screening is a powerful approach to small-molecule discovery, but a major challenge of this strategy lies in determining the intracellular target and mechanism of action (MoA) for validated hits. Here, we show that the small-molecule BRD0476, a novel suppressor of pancreatic β-...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Chou, Danny Hung-Chieh, Vetere, Amedeo, Choudhary, Amit, Scully, Stephen S., Schenone, Monica, Tang, Alicia, Gomez, Rachel, Burns, Sean M., Lundh, Morten, Vital, Tamara, Comer, Eamon, Faloon, Patrick W., Dančík, Vlado, Ciarlo, Christie, Paulk, Joshiawa, Dai, Mingji, Reddy, Clark, Sun, Hanshi, Young, Matthew, Donato, Nicholas, Jaffe, Jacob, Clemons, Paul A., Palmer, Michelle, Carr, Steven A., Schreiber, Stuart L., Wagner, Bridget K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003570/
https://ncbi.nlm.nih.gov/pubmed/26042473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04284
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