Target identification and mechanism of action in chemical biology and drug discovery

Por Schenone, Monica, Dančík, Vlado, Wagner, Bridget K, Clemons, Paul A
Publicado no Nat Chem Biol (2013)

Empirical Bayes Analysis of Quantitative Proteomics Experiments

Por Margolin, Adam A., Ong, Shao-En, Schenone, Monica, Gould, Robert, Schreiber, Stuart L., Carr, Steven A., Golub, Todd R.
Publicado em 2009

Tetracyclines Modify Translation By Targeting Key Human rRNA Substructures

Por Mortison, Jonathan D., Schenone, Monica, Myers, Jacob A., Zhang, Ziyang, Chen, Linfeng, Ciarlo, Christie, Comer, Eamon, Natchiar, S. Kundhavai, Carr, Steven A., Klaholz, Bruno P., Myers, Andrew G.
Publicado no Cell Chem Biol (2018)

The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer

Por Gandhi, Minakshi, Groß, Matthias, Holler, Jessica M., Coggins, Si’Ana A., Patil, Nitin, Leupold, Joerg H., Munschauer, Mathias, Schenone, Monica, Hartigan, Christina R., Allgayer, Heike, Kim, Baek, Diederichs, Sven
Publicado no Nat Commun (2020)

Selective killing of cancer cells with a small molecule targeting stress response to ROS

Por Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U, Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.
Publicado em 2011

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

Por Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U., Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.
Publicado no Nature (2018)

Non-canonical translation via deadenylated 3′UTRs maintains primordial germ cells

Por Jin, Youngnam N., Schlueter, Peter J., Jurisch-Yaksi, Nathalie, Lam, Pui-Ying, Jin, Shan, Hwang, Woong Y., Yeh, Jing-Ruey Joanna, Yoshigi, Masaaki, Ong, Shao-En, Schenone, Monica, Hartigan, Christina R., Carr, Steven A., Peterson, Randall T.
Publicado no Nat Chem Biol (2018)

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

Por Krönke, Jan, Udeshi, Namrata D., Narla, Anupama, Grauman, Peter, Hurst, Slater N., McConkey, Marie, Svinkina, Tanya, Heckl, Dirk, Comer, Eamon, Li, Xiaoyu, Ciarlo, Christie, Hartman, Emily, Munshi, Nikhil, Schenone, Monica, Schreiber, Stuart L., Carr, Steven A., Ebert, Benjamin L.
Publicado em 2013

Castration resistance in prostate cancer is mediated by the kinase NEK6

Por Choudhury, Atish D., Schinzel, Anna C., Cotter, Maura B., Lis, Rosina T., Labella, Katherine, Lock, Ying Jie, Izzo, Francesca, Guney, Isil, Bowden, Michaela, Li, Yvonne Y., Patel, Jinal, Hartman, Emily, Carr, Steven A., Schenone, Monica, Jaffe, Jacob D., Kantoff, Philip W., Hammerman, Peter S., Hahn, William C.
Publicado no Cancer Res (2016)

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation

Por Graham, Daniel B., Lefkovith, Ariel, Deelen, Patrick, de Klein, Niek, Varma, Mukund, Boroughs, Angela, Desch, A. Nicole, Ng, Aylwin C. Y., Guzman, Gaelen, Schenone, Monica, Petersen, Christine P., Bhan, Atul K., Rivas, Manuel A., Daly, Mark J., Carr, Steven A., Wijmenga, Cisca, Xavier, Ramnik J.
Publicado no Cell Rep (2016)

Identifying the proteins to which small-molecule probes and drugs bind in cells

Por Ong, Shao-En, Schenone, Monica, Margolin, Adam A., Li, Xiaoyu, Do, Kathy, Doud, Mary K., Mani, D. R., Kuai, Letian, Wang, Xiang, Wood, John L., Tolliday, Nicola J., Koehler, Angela N., Marcaurelle, Lisa A., Golub, Todd R., Gould, Robert J., Schreiber, Stuart L., Carr, Steven A.
Publicado em 2009

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions

Por Mohanan, Vishnu, Nakata, Toru, Desch, A. Nicole, Lévesque, Chloé, Boroughs, Angela, Guzman, Gaelen, Cao, Zhifang, Creasey, Elizabeth, Yao, Junmei, Boucher, Gabrielle, Charron, Guy, Bhan, Atul K., Schenone, Monica, Carr, Steven A., Reinecker, Hans–Christian, Daly, Mark J., Rioux, John D., Lassen, Kara G., Xavier, Ramnik J.
Publicado no Science (2018)

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8/S100A9

Por Schneider, Rebekka K., Schenone, Monica, Ferreira, Monica Ventura, Kramann, Rafael, Joyce, Cailin E., Hartigan, Christina, Beier, Fabian, Brümmendorf, Tim H., Gehrming, Ulrich, Platzbecker, Uwe, Büsche, Guntram, Knüchel, Ruth, Chen, Michelle C., Waters, Christopher S., Chen, Edwin, Chu, Lisa P., Novina, Carl D., Lindsley, R. Coleman, Carr, Steven A., Ebert, Benjamin L.
Publicado no Nat Med (2016)

Binding of TMPRSS2-ERG to BAF chromatin remodeling complexes mediates prostate oncogenesis

Por Sandoval, Gabriel J., Pulice, John L., Pakula, Hubert, Schenone, Monica A., Takeda, David Y., Pop, Marius, Boulay, Gaylor, Williamson, Kaylyn E., McBride, Matthew J., Pan, Joshua, Pierre, Roodolph St., Hartman, Emily, Garraway, Levi A., Carr, Steven A., Rivera, Miguel N., Li, Zhe, Ronco, Lucienne, Hahn, William C., Kadoch, Cigall
Publicado no Mol Cell (2018)

Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation

Por Basak, Anindita, Munschauer, Mathias, Lareau, Caleb A., Montbleau, Kara E., Ulirsch, Jacob C., Hartigan, Christina R., Schenone, Monica, Lian, John, Wang, Yaomei, Huang, Yumin, Wu, Xianfang, Gehrke, Lee, Rice, Charles M., An, Xiuli, Christou, Helen A., Mohandas, Narla, Carr, Steven A., Chen, Jane-Jane, Orkin, Stuart H., Lander, Eric S., Sankaran, Vijay G.
Publicado no Nat Genet (2020)

Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma

Por Fulciniti, Mariateresa, Martinez-Lopez, Joaquin, Senapedis, William, Oliva, Stefania, Lakshmi Bandi, Rajya, Amodio, Nicola, Xu, Yan, Szalat, Raphael, Gulla, Annamaria, Samur, Mehmet K., Roccaro, Aldo, Linares, Maria, Cea, Michele, Baloglu, Erkan, Argueta, Christian, Landesman, Yosef, Shacham, Sharon, Liu, Siyuan, Schenone, Monica, Wu, Shiaw-Lin, Karger, Barry, Prabhala, Rao, Anderson, Kenneth C., Munshi, Nikhil C.
Publicado no Blood (2017)

Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy

Por Begun, Jakob, Lassen, Kara G., Jijon, Humberto B., Baxt, Leigh A., Goel, Gautam, Heath, Robert J., Ng, Aylwin, Tam, Jenny M., Kuo, Szu-Yu, Villablanca, Eduardo J., Fagbami, Lola, Oosting, Marije, Kumar, Vinod, Schenone, Monica, Carr, Steven A., Joosten, Leo A.B., Vyas, Jatin M., Daly, Mark J., Netea, Mihai G., Brown, Gordon D., Wijmenga, Cisca, Xavier, Ramnik J.
Publicado no Cell Rep (2015)

Identification of cancer cytotoxic modulators of PDE3A by predictive chemogenomics

Por de Waal, Luc, Lewis, Timothy A., Rees, Matthew G., Tsherniak, Aviad, Wu, Xiaoyun, Choi, Peter S., Gechijian, Lara, Hartigan, Christina, Faloon, Patrick W., Hickey, Mark J., Tolliday, Nicola, Carr, Steven A., Clemons, Paul A., Munoz, Benito, Wagner, Bridget K., Shamji, Alykhan F., Koehler, Angela N., Schenone, Monica, Burgin, Alex B., Schreiber, Stuart L., Greulich, Heidi, Meyerson, Matthew
Publicado no Nat Chem Biol (2015)

Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling

Por Chou, Danny Hung-Chieh, Vetere, Amedeo, Choudhary, Amit, Scully, Stephen S., Schenone, Monica, Tang, Alicia, Gomez, Rachel, Burns, Sean M., Lundh, Morten, Vital, Tamara, Comer, Eamon, Faloon, Patrick W., Dančík, Vlado, Ciarlo, Christie, Paulk, Joshiawa, Dai, Mingji, Reddy, Clark, Sun, Hanshi, Young, Matthew, Donato, Nicholas, Jaffe, Jacob, Clemons, Paul A., Palmer, Michelle, Carr, Steven A., Schreiber, Stuart L., Wagner, Bridget K.
Publicado no J Am Chem Soc (2015)

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

Por Viswanathan, Srinivas R., Nogueira, Marina F., Buss, Colin G., Krill-Burger, John M., Wawer, Mathias J., Malolepsza, Edyta, Berger, Ashton C., Choi, Peter S., Shih, Juliann, Taylor, Alison M., Tanenbaum, Benjamin, Pedamallu, Chandra Sekhar, Cherniack, Andrew D., Tamayo, Pablo, Strathdee, Craig A., Lage, Kasper, Carr, Steven A., Schenone, Monica, Bhatia, Sangeeta N., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Meyerson, Matthew
Publicado no Nat Genet (2018)