Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8/S100A9

Heterozygous deletion of RPS14 occurs in del(5q) MDS and has been linked to impaired erythropoiesis, characteristic of this disease subtype. We generated a murine model with conditional inactivation of Rps14 and demonstrated a p53-dependent erythroid differentiation defect with apoptosis at the tran...

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Bibliografiska uppgifter
I publikationen:Nat Med
Huvudupphovsmän: Schneider, Rebekka K., Schenone, Monica, Ferreira, Monica Ventura, Kramann, Rafael, Joyce, Cailin E., Hartigan, Christina, Beier, Fabian, Brümmendorf, Tim H., Gehrming, Ulrich, Platzbecker, Uwe, Büsche, Guntram, Knüchel, Ruth, Chen, Michelle C., Waters, Christopher S., Chen, Edwin, Chu, Lisa P., Novina, Carl D., Lindsley, R. Coleman, Carr, Steven A., Ebert, Benjamin L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870050/
https://ncbi.nlm.nih.gov/pubmed/26878232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4047
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