KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma

Por Zheng, Yun, Gery, Sigal, Sun, Haibo, Shacham, Sharon, Kauffman, Michael, Koeffler, H. Phillip
Publicado em 2014

Heterozygous mutation of cysteine(528) in XPO1 is sufficient for resistance to selective inhibitors of nuclear export

Por Neggers, Jasper Edgar, Vanstreels, Els, Baloglu, Erkan, Shacham, Sharon, Landesman, Yosef, Daelemans, Dirk
Publicado no Oncotarget (2016)

Specific Inhibition of the Nuclear Exporter Exportin-1 Attenuates Kidney Cancer Growth

Por Wettersten, Hiromi I., Landesman, Yosef, Friedlander, Sharon, Shacham, Sharon, Kauffman, Michael, Weiss, Robert H.
Publicado no PLoS One (2014)

Nucleo-cytoplasmic transport as a therapeutic target of cancer

Por Gravina, Giovanni Luca, Senapedis, William, McCauley, Dilara, Baloglu, Erkan, Shacham, Sharon, Festuccia, Claudio
Publicado no J Hematol Oncol (2014)

CRM1 Blockade by Selective Inhibitors of Nuclear Export (SINE) attenuates Kidney Cancer Growth

Por Inoue, Hiromi, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef, Yang, Joy, Evans, Christopher P., Weiss, Robert H.
Publicado no J Urol (2012)

Selective inhibitors of nuclear export for the treatment of non-Hodgkin’s lymphomas

Por Azmi, Asfar S., Al-Katib, Ayad, Aboukameel, Amro, McCauley, Dilara, Kauffman, Michael, Shacham, Sharon, Mohammad, Ramzi M.
Publicado em 2013

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer

Por Gao, Jiankun, Azmi, Asfar S., Aboukameel, Amro, Kauffman, Michael, Shacham, Sharon, Abou-Samra, Abdul-Badi, Mohammad, Ramzi M.
Publicado em 2014

The effects of PRX-07034, a novel 5-HT(6) antagonist, on cognitive flexibility and working memory in rats

Por Mohler, Eric G., Baker, Phillip M., Gannon, Kimberly S., Jones, Simon S., Shacham, Sharon, Sweeney, John A., Ragozzino, Michael E.
Publicado em 2011

XPO1 Inhibition Preferentially Disrupts the 3D Nuclear Organization of Telomeres in Tumor Cells

Por Taylor‐Kashton, Cheryl, Lichtensztejn, Daniel, Baloglu, Erkan, Senapedis, William, Shacham, Sharon, Kauffman, Michael G., Kotb, Rami, Mai, Sabine
Publicado no J Cell Physiol (2016)

Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice

Por Azmi, Asfar S., Aboukameel, Amro, Bao, Bin, Sarkar, Fazlul H., Philip, Philip A., Kauffman, Michael, Shacham, Sharon, Mohammad, Ramzi M.
Publicado em 2012

XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple negative breast cancer

Por Cheng, Yan, Holloway, Michael P, Nguyen, Kevin, McCauley, Dilara, Landesman, Yosef, Kauffman, Michael G, Shacham, Sharon, Altura, Rachel A
Publicado em 2014

A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds

Por Crochiere, Marsha L., Baloglu, Erkan, Klebanov, Boris, Donovan, Scott, del Alamo, Diego, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Publicado no Oncotarget (2015)

CRM1 Inhibition Sensitizes Drug Resistant Human Myeloma Cells to Topoisomerase II and Proteasome Inhibitors both In Vitro and Ex Vivo

Por Turner, Joel G., Dawson, Jana, Emmons, Michael F., Cubitt, Christopher L., Kauffman, Michael, Shacham, Sharon, Hazlehurst, Lori A., Sullivan, Daniel M.
Publicado em 2013

G protein-coupled receptors: In silico drug discovery in 3D

Por Becker, Oren M., Marantz, Yael, Shacham, Sharon, Inbal, Boaz, Heifetz, Alexander, Kalid, Ori, Bar-Haim, Shay, Warshaviak, Dora, Fichman, Merav, Noiman, Silvia
Publicado em 2004

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

Por Mendonca, Janet, Sharma, Anup, Kim, Hae-Soo, Hammers, Hans, Meeker, Alan, De Marzo, Angelo, Carducci, Michael, Kauffman, Michael, Shacham, Sharon, Kachhap, Sushant
Publicado em 2014

A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus

Por Tajiri, Naoki, De La Peña, Ike, Acosta, Sandra A., Kaneko, Yuji, Tamir, Sharon, Landesman, Yosef, Carlson, Robert, Shacham, Sharon, Borlongan, Cesar V.
Publicado no CNS Neurosci Ther (2016)

Novel p21-activated kinase 4 (PAK4) allosteric modulators overcome drug resistance and stemness in pancreatic ductal adenocarcinoma

Por Aboukameel, Amro, Muqbil, Irfana, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael, Philip, Philip A., Mohammad, Ramzi M., Azmi, Asfar S.
Publicado no Mol Cancer Ther (2016)

Antiviral Efficacy of Verdinexor In Vivo in Two Animal Models of Influenza A Virus Infection

Por Perwitasari, Olivia, Johnson, Scott, Yan, Xiuzhen, Register, Emery, Crabtree, Jackelyn, Gabbard, Jon, Howerth, Elizabeth, Shacham, Sharon, Carlson, Robert, Tamir, Sharon, Tripp, Ralph A.
Publicado no PLoS One (2016)

Verdinexor, a Novel Selective Inhibitor of Nuclear Export, Reduces Influenza A Virus Replication In Vitro and In Vivo

Por Perwitasari, Olivia, Johnson, Scott, Yan, Xiuzhen, Howerth, Elizabeth, Shacham, Sharon, Landesman, Yosef, Baloglu, Erkan, McCauley, Dilara, Tamir, Sharon, Tompkins, S. Mark, Tripp, Ralph A.
Publicado em 2014

Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines

Por Breit, Megan N, Kisseberth, William C, Bear, Misty D, Landesman, Yosef, Kashyap, Trinayan, McCauley, Dilara, Kauffman, Michael G, Shacham, Sharon, London, Cheryl A
Publicado em 2014