Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

Mislocalization of proteins is a common feature of cancer cells. Since localization of proteins is tightly linked to its function, cancer cells can inactivate function of a tumor suppressor protein through mislocalization. The nuclear exportin CRM1/XPO 1 is upregulated in many cancers. Targeting XPO...

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Main Authors: Mendonca, Janet, Sharma, Anup, Kim, Hae-Soo, Hammers, Hans, Meeker, Alan, De Marzo, Angelo, Carducci, Michael, Kauffman, Michael, Shacham, Sharon, Kachhap, Sushant
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2014
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171616/
https://ncbi.nlm.nih.gov/pubmed/25026284
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