A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds

Selective Inhibitor of Nuclear Export (SINE) compounds are a family of small-molecules that inhibit nuclear export through covalent binding to cysteine 528 (Cys528) in the cargo-binding pocket of Exportin 1 (XPO1/CRM1) and promote cancer cell death. Selinexor is the lead SINE compound currently in p...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Crochiere, Marsha L., Baloglu, Erkan, Klebanov, Boris, Donovan, Scott, del Alamo, Diego, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811503/
https://ncbi.nlm.nih.gov/pubmed/26654943
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