Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer related deaths in the United States with a majority of these patients dying from aggressively invasive and metastatic disease. There is growing evidence that suggests an important role for microRNAs (miRNAs) in the pathobio...

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Pubblicato in:Oncotarget
Autori principali: Azmi, Asfar S., Li, Yiwei, Muqbil, Irfana, Aboukameel, Amro, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael G., Philip, Philip A., Mohammad, Ramzi M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669877/
https://ncbi.nlm.nih.gov/pubmed/29137251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19285
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